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FACIAL NV Niacinamide BACK Features 1. Ative Ingredients Niacinamide. 2. Benefits Skin barrier regeneration; Cellular renewal; Photoaging prevention; Blue light protection; Acne vulgaris treatment; Antioxidant properties; Standardizes skin tone and reduces pallor; Adjuvant in the care of atopic dermatitis and rosacea. 3. Usage Primers; Creams; Masks; Serums; Gels; Face and eye cream gels; Liquid soaps; Makeup removers; Skin tone standardizing products. 4. Properties Vegan Cruelty Free Cdial Halal Download Technical Sheet Request sample NV NIACINAMIDE The Niacinamide encapsulation through Nanovetores Technology enables the smart and safe delivery of the active ingredient, with a significant increase in stability, ensuring greater cosmetic products efficiency. ​ NV Niacinamide nanoparticles are characterized by an average size greater than 200 nm. In addition to safety, they offer active protection against hydrolysis, common to carbonyl structures, such as Niacinamide. Another advantage of NV Niacinamide is the substance skin permeation improvement , which reaches the dermis in its active form, without loss through degradation. With greater compatibility with chemical ingredients and reduced irritant effects such as burning, itching, and erythema, NV Niacinamide is a superior alternative for cosmetic formulations. Mechanism of Action The effect of niacinamide on the skin surface structure can be seen to improve its appearance, including reduction of fine lines and wrinkles, hyperpigmented spots, paleness, and improved skin elasticity. Since NADH and NADPH are antioxidants, a possible effect of topically applied niacinamide is to increase the levels of these antioxidants and consequently to inhibit oxidative processes, such as collagen glycation. These oxidative processes play a significant role in skin aging, in addition to impacting the yellowish or pale appearance of the skin, due to the Maillard reaction, which forms yellow compounds . Niacinamide increases the rate of cell renewal and has a stimulating effect on the synthesis of collagen, keratin from epidermal biopolymers (proteins), filaggrin, and involucrin. Decreased skin pigmentation can also be observed by the suppressive effect of niacinamide, transfer of melanosomes from melanocytes to keratinocytes, and photoprotective effect related to the reduction of oxidative stress, reducing damage caused by blue light. ​ In the treatment of acne vulgaris, niacinamide can contribute with its seborregulatory effect, anti-inflammatory and curative properties, decrease in the number of pustules, comedones, and papules. It significantly reduces the expression of inflammatory mediators produced by keratinocytes such as: IL-6, IL-10, MCP-1, and TNF-a mRNA responsible for tissue damage. Furthermore, niacinamide may exert direct control over Propionibacterium acne as a result of inhibition of Sir2 10,11,12 enzymes. Due to its numerous benefits, niacinamide has proved to be a versatile active for cosmetic application Let's talk? Subscibe to our newsletter Send Nanovetores is a company that produces high performance active ingredients for pharmaceutical and cosmetic industries. By submitting your data, you agree with our Privacy Policy , in accordance with the data protection law.

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FACIAL NV Cysteamine 15 BACK Features 1. Ative Ingredients Cysteamine HCL 2. Benefits Antioxidant; Illuminates the skin; Evens skin tone; Hyperpigmentation and Malasma tratment. 3. Usage Gels; Facial gel-cream; Emulsions; Masks; Serums; Products to standardize skin tone. 4. Properties Vegan Cruelty free Cdial Halal Download Technical Sheet Request sample NV Cysteamine 15 Nanovetores innovative encapsulation system enables the intelligent and safe delivery of Cysteamine while also ensures greater cosmetics efficacy and stability for the treatment of hyperpigmentation and Melasma. ​ Cysteamine is a very challenging ingredient to work with, our encapsulated version grants the following benefits: ​ •Active ingredient stabilization; •Improved active permeation and diffusion through the skin layers; •Controlled release; •Improved illumination efficacy; •Reduction of the active’s irritating effects on the skin; •Better treatment adherence; •Acts in the barrier function maintenance preventing transepidermal water loss. CYSTEAMINE Cysteamine (CSH) is a reducing aminothiol naturally formed in the body from the conversion of coenzyme A to pantetheine. Considered one of the most potent intracellular antioxidants, Cysteamine cell redox homeostasis. Cysteamine skin lightening effect is attributed to its antioxidant properties, with direct action in the stratum corneum. With a mechanism of action that involves its capacity to reduce melanin production, by inhibition of essential melanogenic enzymes , tyrosinase and peroxidase, also has a chelating effect on the copper ions needed in melanogenesis. Besides the antioxidant properties, the free thiol group of Cysteamine can interact with the disulfide bonds of peptides and proteins, and interfere in their functions. This way, cysteamine can act in several signaling pathways involved in proliferation, survival and influence on the expression of several redox-sensitive cellular genes. ​ Despite its innumerous and noticeable biological applications, cysteamine commercial potential is limited due to its unpleasant odor (attributed to the sulfur present in the molecule). Besides this, hygroscopicity, poor pharmacokinetic profile and the fact that cysteamine is highly susceptible to degradation due to its rapid oxidation by air difficult its application. With the goal to overcome these challenges, Nanovetores encapsulation technology is capable to reduce the active’s odor, enhance its stability and make the incorporation in cosmetic products easier. This improvement in the organoleptic characteristics makes the use of Cysteamine more pleasant, reducing skin irritation and allowing its continuous use, with superior results in the treatment of hyperpigmentation and Melasma. Let's talk? Subscibe to our newsletter Send Nanovetores is a company that produces high performance active ingredients for pharmaceutical and cosmetic industries. By submitting your data, you agree with our Privacy Policy , in accordance with the data protection law.